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Table 1 IC50 values of the extract and fractions on AR inhibition

From: Plant-derived molecules from Saussurea grandifolia as inhibitors of aldose reductase

Sample

Concentration

(μg/mL)

Inhibitiona (%)

IC b50 (μg/mL)

MeOH extract

5

85.19

0.84

1

56.64

0.5

37.16

n-Hexane fraction

10

21.58

MC fraction

10

46.48

EtOAc fraction

1

93.41

0.12

0.1

57.21

0.05

24.37

n-BuOH fraction

10

84.07

3.33

5

67.28

1

8.67

TMGc

5

78.48

0.96

1

58.96

0.5

32.16

  1. aInhibition rate was calculated as a percentage with respect to the control value
  2. bIC50 value was calculated from least-squares regression analysis of the plot of the logarithm of three graded concentrations versus % inhibition
  3. cTMG was used as a positive control