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Fig. 2 | Applied Biological Chemistry

Fig. 2

From: Iron-dextran as a thermosensitizer in radiofrequency hyperthermia for cancer treatment

Fig. 2

Iron-dextran boosted temperature elevation in cancer-bearing mice upon 13.56 MHz RF hyperthermia. a Schematic drawing of vasculature in cancer and normal tissues. The excessive heat in the cancer tissues is difficult to be diffused into other parts of body via blood flow, resulting cancer tissues more vulnerable to hyperthermic oncotherapy. b H&E staining of cancer tissue showed the abnormal chaotic vasculature with active angiogenesis and slowed blood flow. Scale bar, 100 µm. c The temperature elevation in tumor tissue was dramatically boosted by local hyperthermia using 13.56 MHz RF wave with iron-dextran but not with dextran. Data represent the mean ± SD (n = 6). Asterisk indicates statistical significance as analyzed by a paired Student’s t-test; ***p < 0.001 with the division

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