Fig. 4

The oncotherapeutic efficacy of iron-dextran as a thermosensitizer in a local 13.56 MHz RF hyperthermia. a The in vivo evaluation results of oncotherapeutic efficacy of iron-dextran as a thermosensitizer in the local 13.56 MHz RF hyperthermia in a tumor-xenografted mouse model. b The representative in vivo bioimage of the tumor-xenografted mice to evaluate the oncotherapeutic efficacy of iron-dextran as a thermosensitizer in 13.56 MHz RF hyperthermia. c The representative histological images of the cancer tissues of the tumor-xenografted mice after each treatment. The abbreviation in this figure, Ctrl; control mice with dextran injection, Ctrl + HT; control mice with dextran injection followed by local treatment of 13.56 MHz RF hyperthermia, ID; mice with iron-dextran injection only, ID + HT; mice with iron-dextran injection as a thermosensitizer followed by local treatment of 13.56 MHz RF hyperthermia, Paclitaxel; mice in which equivalent dose of paclitaxel was injected as a chemotherapeutic agent without RF hyperthermia treatment. Necrosis of tumor tissue is indicated by an arrow. The values represent the mean ± standard deviation (n = 6). A paired Student’s t-test was used for the statistical analysis; *** p < 0.001. Scale bar, 50 µm