Fig. 3From: Synthesis and anticancer activities of polymethylenedioxy analogues of combretastatin A-2Atomic charges of surface area of binding pocket of β-tubulin in 5LYJ (a), and those of CA-4 (b) and stilbene 3 (c). Blue color for positive and red for negative charges. Dotted circle and rectangles are for 4-methoxy (or 4-trifluoromethoxy substituents) Values in insert B and C are partial charges of hydrogen or fluorine atoms in CA-4 and 3Back to article page