From: Synthesis and anticancer activities of polymethylenedioxy analogues of combretastatin A-2
ID | Antiproliferative activity IC50 (μM ± SD) | Antioxidant activity IC50 (mg/mL ± SD)a | ||||||
---|---|---|---|---|---|---|---|---|
HeLa | SK-OV-3 | A549 | HT-29 | HaCaT | MDCK | DPPH | ABTS | |
1 | 7.78 ± 0.50 | 20.25 ± 2.00 | 269.11 ± 6.46 | 0.009 ± 0.000 | 55.09 ± 0.48 | 40.31 ± 0.26 | 4.65 ± 0.02 | 1.56 ± 0.02 |
2 | 1.19 ± 0.25 | 1.66 ± 0.18 | 11.26 ± 0.16 | 0.020 ± 0.003 | 60.83 ± 1.14 | 50.1 ± 0.34 | 72.71 ± 3.02 | 99.28 ± 2.75 |
3 | 17.96 ± 2.23 | 480.99 ± 5.76 | 190.46 ± 0.81 | 0.440 ± 0.081 | 53.98 ± 0.49 | 120.07 ± 2.14 | 90.79 ± 2.22 | 94.08 ± 0.67 |
4 | 6.44 ± 0.64 | 333.35 ± 6.95 | 173.18 ± 1.08 | 0.104 ± 0.030 | 68.42 ± 3.68 | 100.47 ± 1.25 | 33.19 ± 0.26 | 99.48 ± 0.15 |
5 | 3.59 ± 0.30 | 162.50 ± 1.72 | 98.02 ± 2.38 | 0.090 ± 0.001 | 57.5 ± 3.36 | 98.59 ± 1.80 | 30.08 ± 1.12 | 99.66 ± 0.82 |
6 | 5.35 ± 0.26 | 50.30 ± 0.18 | 9.29 ± 0.35 | 0.482 ± 0.021 | 56.04 ± 0.11 | 111.10 ± 1.58 | 67.30 ± 2.64 | 78.06 ± 1.27 |
7 | 130.86 ± 3.01 | 213.55 ± 5.38 | 122.37 ± 0.25 | 0.110 ± 0.001 | 84.40 ± 0.08 | 233.45 ± 2.02 | 66.30 ± 0.25 | 98.49 ± 1.94 |
8 | 52.18 ± 1.00 | 125.31 ± 0.63 | 261.52 ± 6.59 | 0.006 ± 0.000 | 41.07 ± 3.14 | 66.84 ± 1.02 | 5.71 ± 0.05 | 2.79 ± 0.01 |
9 | 26.88 ± .43 | 147.67 ± 0.16 | 164.5 ± 8.70 | 0.280 ± 0.030 | 107.83 ± 0.80 | 101.53 ± 1.16 | 89.81 ± 0.73 | 98.18 ± 0.96 |
10 | 9.73 ± 0.71 | 460.91 ± 12.1 | 202.01 ± 2.19 | 0.479 ± 0.106 | 135.28 ± 4.39 | 151.27 ± 0.75 | 34.78 ± 0.75 | 84.11 ± 0.35 |
11 | 8.55 ± 0.67 | 165.43 ± 0.54 | 239.46 ± 9.31 | 0.047 ± 0.010 | 131.68 ± 2.53 | 130.17 ± 2.67 | 64.12 ± 0.68 | 93.34 ± 0.94 |
12 | 191.63 ± 2.47 | 136.54 ± 1.46 | 204.97 ± 5.75 | 1.907 ± 0.013 | 102.34 ± 2.06 | 375.61 ± 6.90 | 64.18 ± 2.18 | 88.41 ± 1.04 |
13 | 89.52 ± 1.34 | 121.47 ± 0.52 | 110.61 ± 0.17 | 0.433 ± 0.117 | 71.75 ± 1.12 | 222.76 ± 1.55 | 54.80 ± 3.18 | 83.45 ± 1.19 |
14 | 200.65 ± 3.22 | 288.13 ± 4.22 | 332.12 ± 9.48 | 1.218 ± 0.020 | 135.57 ± 1.68 | 1540.3 ± 9.98 | 70.62 ± 3.31 | 96.93 ± 3.53 |