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Table 1 Antiproliferative activity of combretastatin A-4 and polymethylenedioxy analogues on various tumor cell lines and normal cells and antioxidant activities

From: Synthesis and anticancer activities of polymethylenedioxy analogues of combretastatin A-2

ID

Antiproliferative activity

IC50 (μM ± SD)

Antioxidant activity

IC50 (mg/mL ± SD)a

HeLa

SK-OV-3

A549

HT-29

HaCaT

MDCK

DPPH

ABTS

1

7.78 ± 0.50

20.25 ± 2.00

269.11 ± 6.46

0.009 ± 0.000

55.09 ± 0.48

40.31 ± 0.26

4.65 ± 0.02

1.56 ± 0.02

2

1.19 ± 0.25

1.66 ± 0.18

11.26 ± 0.16

0.020 ± 0.003

60.83 ± 1.14

50.1 ± 0.34

72.71 ± 3.02

99.28 ± 2.75

3

17.96 ± 2.23

480.99 ± 5.76

190.46 ± 0.81

0.440 ± 0.081

53.98 ± 0.49

120.07 ± 2.14

90.79 ± 2.22

94.08 ± 0.67

4

6.44 ± 0.64

333.35 ± 6.95

173.18 ± 1.08

0.104 ± 0.030

68.42 ± 3.68

100.47 ± 1.25

33.19 ± 0.26

99.48 ± 0.15

5

3.59 ± 0.30

162.50 ± 1.72

98.02 ± 2.38

0.090 ± 0.001

57.5 ± 3.36

98.59 ± 1.80

30.08 ± 1.12

99.66 ± 0.82

6

5.35 ± 0.26

50.30 ± 0.18

9.29 ± 0.35

0.482 ± 0.021

56.04 ± 0.11

111.10 ± 1.58

67.30 ± 2.64

78.06 ± 1.27

7

130.86 ± 3.01

213.55 ± 5.38

122.37 ± 0.25

0.110 ± 0.001

84.40 ± 0.08

233.45 ± 2.02

66.30 ± 0.25

98.49 ± 1.94

8

52.18 ± 1.00

125.31 ± 0.63

261.52 ± 6.59

0.006 ± 0.000

41.07 ± 3.14

66.84 ± 1.02

5.71 ± 0.05

2.79 ± 0.01

9

26.88 ± .43

147.67 ± 0.16

164.5 ± 8.70

0.280 ± 0.030

107.83 ± 0.80

101.53 ± 1.16

89.81 ± 0.73

98.18 ± 0.96

10

9.73 ± 0.71

460.91 ± 12.1

202.01 ± 2.19

0.479 ± 0.106

135.28 ± 4.39

151.27 ± 0.75

34.78 ± 0.75

84.11 ± 0.35

11

8.55 ± 0.67

165.43 ± 0.54

239.46 ± 9.31

0.047 ± 0.010

131.68 ± 2.53

130.17 ± 2.67

64.12 ± 0.68

93.34 ± 0.94

12

191.63 ± 2.47

136.54 ± 1.46

204.97 ± 5.75

1.907 ± 0.013

102.34 ± 2.06

375.61 ± 6.90

64.18 ± 2.18

88.41 ± 1.04

13

89.52 ± 1.34

121.47 ± 0.52

110.61 ± 0.17

0.433 ± 0.117

71.75 ± 1.12

222.76 ± 1.55

54.80 ± 3.18

83.45 ± 1.19

14

200.65 ± 3.22

288.13 ± 4.22

332.12 ± 9.48

1.218 ± 0.020

135.57 ± 1.68

1540.3 ± 9.98

70.62 ± 3.31

96.93 ± 3.53

  1. aIC50s of reference compound (ascorbic acid) for DPPH and ABTS assay were 8.43 ± 0.21 and 22.41 ± 0.24 mg/mL, respectively