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Table 2 Binding free energies and surface area of combretastatin A-4 and polymethylenedioxy analogues of combretastatin A-2

From: Synthesis and anticancer activities of polymethylenedioxy analogues of combretastatin A-2

Compounds

Free energyb

Surface areac

Compounds

Free energy

Surface area

1(Z) a

− 8.9149

562.98

8(E)

− 8.2185

574.25

2(Z)

− 8.5054

555.73

9(E)

− 7.9875

567.55

3(Z)

− 8.0018

564.28

10(E)

− 7.8679

585.66

4(Z)

− 8.06606

500.69

11(E)

− 7.8868

522.57

5(Z)

− 8.1496

539.12

12(E)

− 7.7385

546.08

6(Z)

− 8.0908

561.26

13(E)

− 7.6235

570.91

7(Z)

− 8.2103

585.55

14(E)

− 7.5486

589.23

  1. aThe geometry of stilbenes were described as (Z) for cis-isomers and (E) for trans-isomers
  2. bBinding free energy ΔG in kcal/mol
  3. cSurface area (square angstrom/mol)