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Applied Biological Chemistry
Fig. 1 | Applied Biological Chemistry

Fig. 1

From: Antimelanogenic activities of piperlongumine derived from Piper longum on murine B16F10 melanoma cells in vitro and zebrafish embryos in vivo: its molecular mode of depigmenting action

Fig. 1

a Structure of piperlongumine; b viability of murine B16F10 cells in response to increasing concentrations of piperlongumine; c expression levels after treatment of α-melanocyte stimulating hormone. Mitf, microphthalmia associated transcription factor; Tyr, tyrosinase; Trp-1, tyrosinase-related protein 1; and Trp-2, tyrosinase-related protein 2. Significant differences are expressed by the symbols *, **, ***, and **** as p < 0.05, p < 0.01, p < 0.001, and p < 0.0001, respectively

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