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Applied Biological Chemistry
Fig. 4 | Applied Biological Chemistry

Fig. 4

From: Antimelanogenic activities of piperlongumine derived from Piper longum on murine B16F10 melanoma cells in vitro and zebrafish embryos in vivo: its molecular mode of depigmenting action

Fig. 4

Inhibitory effects of piperlongumine (PL) on melanin production in zebrafish embryos (Danio rerio). a Images of depigmentation in the head of zebrafish embryos after treatment with PL. Kojic acid (KA, 8 mM) was used as a positive control. b Images of the development of zebrafish embryos to larvae after chemical treatment at embryo stages. PL exhibits potent developmental toxicity with spine curvature at 2 μM. c Melanin production in zebrafish embryos after treatment with the indicated chemicals. Con, control. Significant differences are expressed by the symbols *, **, ***, and **** as p < 0.05, p < 0.01, p < 0.001, and p < 0.0001, respectively

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