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Applied Biological Chemistry
Fig. 2 | Applied Biological Chemistry

Fig. 2

From: Methyl lucidone exhibits neuroprotective effects on glutamate-induced oxidative stress in HT-22 cells via Nrf-2/HO-1 signaling

Fig. 2

MLC suppresses glutamate-induced ROS production in HT-22 cells. a After pretreating with MLC (1, 3, 5 μM) for 1 h, the cells were washed and further incubated with glutamate (5 mM) for 12 h in the absence of MLC. Intracellular ROS levels were measured using ROS-sensitive fluorescent DCF-DA. **p < 0.01, compared to cells not treated with any drugs (0 μM MLC and − Glu), and ##p < 0.01, compared to the group treated with glutamate alone at 0 μM MLC. b DPPH assay was performed to measure the antioxidative effect of MLC and the rate of free radical scavenging activities was calculated as inhibition rate (%). **p < 0.01, compared to cells not treated any drugs. The data indicate mean ± SEM (n = 3)

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