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Table 1 Inhibitory effects of compounds on HNE

From: Human neutrophil elastase inhibitory dihydrobenzoxanthones and alkylated flavones from the Artocarpus elasticus root barks

Compounds

ICa50 (μM)

Inhibition mode (Kbi , μM)

KI (μM)

KIS (μM)

1

> 300

NT

NT

NT

2

14.8 ± 0.4

Noncompetitive (12.6 ± 0.2)

NT

NT

3

16.0 ± 0.4

Noncompetitive (15.4 ± 0.4)

NT

NT

4

18.1 ± 0.3

Noncompetitive (17.7 ± 0.6)

NT

NT

5

9.8 ± 0.1

Mixed (6.4 ± 0.5)

6.5

31.8

6

11.2 ± 0.1

Mixed (4.7 ± 0.5)

4.7

19.9

7

20.8 ± 0.3

Mixed (13.7 ± 0.2)

13.8

46.9

8

28.7 ± 0.7

Mixed (19.4 ± 0.3)

17.5

31.2

Caffeic acidc

67.1 ± 0.2

NT

NT

NT

  1. NT not tested
  2. aSample concentration which led to 50% enzyme activity loss
  3. bKi is the inhibition constant
  4. cThe positive control