Compounds | ICa50 (μM) | Inhibition mode (Kbi , μM) | KI (μM) | KIS (μM) |
---|---|---|---|---|
1 | > 300 | NT | NT | NT |
2 | 14.8 ± 0.4 | Noncompetitive (12.6 ± 0.2) | NT | NT |
3 | 16.0 ± 0.4 | Noncompetitive (15.4 ± 0.4) | NT | NT |
4 | 18.1 ± 0.3 | Noncompetitive (17.7 ± 0.6) | NT | NT |
5 | 9.8 ± 0.1 | Mixed (6.4 ± 0.5) | 6.5 | 31.8 |
6 | 11.2 ± 0.1 | Mixed (4.7 ± 0.5) | 4.7 | 19.9 |
7 | 20.8 ± 0.3 | Mixed (13.7 ± 0.2) | 13.8 | 46.9 |
8 | 28.7 ± 0.7 | Mixed (19.4 ± 0.3) | 17.5 | 31.2 |
Caffeic acidc | 67.1 ± 0.2 | NT | NT | NT |