Table 2 Significantly altered metabolites of zebrafish exposed to lindane in targeted metabolomics (VIP > 1.0, SE < 1.0, and p-value < 0.05)
From: Toxicometabolomics of lindane in adult zebrafish (Danio rerio) using GC-MS/MS and LC-Orbitrap-MS/MS
No. | Compound name | VIP | Standard error | P value | No. | Compound name | VIP | Standard error | P value | No. | Compound name | VIP | Standard error | P value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Hypoxanthine | 1.35 | 0.49 | 1.41E−06 | 16 | 3-Aminoglutaric acid | 1.19 | 0.39 | 3.69E−04 | 31 | Ribulose 5-phosphate | 1.23 | 0.62 | 5.52E−03 |
2 | 2-Aminoethanol | 1.38 | 0.55 | 1.44E−06 | 17 | Palmitic acid | 1.31 | 0.29 | 4.73E−04 | 32 | Docosahexaenoic acid | 1.03 | 0.59 | 6.42E−03 |
3 | Lysine | 1.31 | 0.28 | 7.29E−06 | 18 | Proline | 1.16 | 0.39 | 5.91E−04 | 33 | Arachidonic acid | 1.01 | 0.58 | 7.45E−03 |
4 | Tyramine | 1.31 | 0.28 | 9.58E−06 | 19 | Leucine | 1.15 | 0.39 | 6.81E−04 | 34 | Eicosapentaenoic acid | 1.00 | 0.57 | 7.52E−03 |
5 | Xanthine | 1.26 | 0.46 | 2.69E−05 | 20 | Methionine | 1.13 | 0.39 | 9.15E−04 | 35 | 6−Phosphogluconic acid | 1.00 | 0.48 | 7.90E−03 |
6 | Gluconic acid | 1.32 | 0.29 | 3.69E−05 | 21 | Monostearin | 1.16 | 0.44 | 9.40E−04 | 36 | Palmitoleic acid | 1.00 | 0.60 | 8.30E−03 |
7 | Mannose 6-phosphate | 1.28 | 0.29 | 3.92E−05 | 22 | Tyrosine | 1.10 | 0.45 | 1.71E−03 | 37 | Myristic acid | 1.02 | 0.51 | 8.62E−03 |
8 | Glucose | 1.28 | 0.36 | 5.09E−05 | 23 | Ribose | 1.11 | 0.71 | 2.25E−03 | 38 | Heptadecanoic acid | 1.44 | 0.57 | 9.43E−03 |
9 | Glucose 6-phosphate | 1.26 | 0.31 | 7.23E−05 | 24 | Oleic acid | 1.09 | 0.52 | 2.62E−03 | 39 | Ribose 5−phosphate | 1.28 | 0.77 | 1.55E−02 |
10 | gluconic acid lactone | 1.26 | 0.39 | 1.01E−04 | 25 | Elaidic acid | 1.08 | 0.53 | 2.70E−03 | 40 | Stearic acid | 1.32 | 0.57 | 2.18E−02 |
11 | Valine | 1.23 | 0.26 | 1.19E−04 | 26 | Glyceric acid | 1.15 | 0.53 | 2.73E−03 | 41 | Glutamic acid | 1.41 | 0.96 | 2.51E−02 |
12 | Sedoheptulose 7-phosphate | 1.22 | 0.51 | 1.40E−04 | 27 | Creatinine | 1.21 | 0.64 | 2.95E−03 | 42 | Methyl serine | 1.51 | 0.78 | 2.55E−02 |
13 | Isoleucine | 1.19 | 0.39 | 2.84E−04 | 28 | Tryptophan | 1.05 | 0.58 | 3.00E−03 | 43 | Threonine | 1.00 | 0.64 | 2.58E−02 |
14 | Aspartic acid | 1.21 | 0.39 | 3.31E−04 | 29 | Alanine | 1.07 | 0.43 | 4.40E−03 | 44 | Caproic acid | 1.58 | 0.66 | 2.94E−02 |
15 | Phenylalanine | 1.18 | 0.36 | 3.51E−04 | 30 | Uracil | 1.05 | 0.49 | 5.34E−03 | 45 | Histidine | 1.13 | 0.52 | 3.12E−02 |