Fig. 4
From: Anti-acne effects of Castanea crenata bur extract and identification of active compound
CBE inhibits TLR2-mediated inflammatory pathway induced by C. acnes and PA in HEK293-TLR2 cells. A The HEK293-TLR2 cells were cultured in serum-free conditions and treated with C. acnes CM or C. acnes CBE. B The HEK293-TLR2 cells were cultured in serum-free conditions, treated with C. acnes CM, and CBE were added for 6 h. C The HEK293-TLR2 cells were cultured in serum-free conditions and PA was treated with or without CBE for 18 h. TLR2 activity was measured through the secreted alkaline phosphatase. The values are expressed compared to the control, which was considered to be 100% (n = 3). The data are presented as the mean ± SD, *P < 0.05 compared to the control group