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Applied Biological Chemistry
Fig. 3 | Applied Biological Chemistry

Fig. 3

From: Glycyrrhiza uralensis attenuates TNF-α-induced muscle atrophy in myoblast cells through the Nrf2 and MAFbx signaling cascades

Fig. 3

Glycyrrhiza uralensis reduced protein levels of atrophy markers and E3 ligase in C2C12 myotubes. Myotubes were induced for 5 days and treated with TNF-α to establish a model of atrophy. C2C12 cells were treated in the presence or absence of TNF-α (10 ng/mL) and GU (10, 50, and 100 μg/mL) for 24 h. The expression levels of muscle atrophy F-box, muscle RING-finger protein-1, and Smad3 proteins were measured by western blot analysis. Data are presented as the means ± standard error of the means (SEMs) of three independent experiments

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