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Fig. 5 | Applied Biological Chemistry

Fig. 5

From: Insulin secretion and α-glucosidase inhibitory effects of dicaffeoylquinic acid derivatives

Fig. 5

Effect of 4,5-Dicaffeoylquinic acid (4,5-DCQA) on the expression levels of phospho-Akt (P-Akt) (Ser473), Akt, phospho-extracellular signal-regulated protein kinases (ERK), ERK, phospho-insulin receptor substrate-2 (P-IRS-2), (Ser731), IRS-2, phospho-phosphoinositide 3-kinase (P-PI3K), PI3K, and pancreatic and duodenal homeobox-1 (PDX-1) proteins in INS-1 cells. A The expression levels of P-ERK, ERK, P-IRS-2 (Ser731), IRS-2, P-PI3K, PI3K, P-Akt (Ser473), Akt, PDX-1, and GAPDH proteins in INS-1 cells treated or untreated with 4,5-DCQA at concentrations of 2.5, 5 and 10 μM for 24 h. B Densitometric quantification graphs of the Western blotting bands (n = 3 independent experiments). The data are presented as the mean ± SEM. *P < 0.05 compare with not-treated group

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