Propofol limited NSCLC cell malignant behaviors by regulating circ_0001727. A Circ_0001727 level was examined in NSCLC cells transfected with si-NC or si-circ_0001727. B–I NSCLC cells were divided into 4 groups: control group, propofol group, propofol + si-NC group, and propofol + si-circ_0001727 group. B CCK-8 analysis was applied for detecting cell viability. C Cell colony-forming ability was evaluated by colony formation assay. Cell migration (D) invasion (E) were evaluated using transwell assay (× 100). F Angiogenesis was determined by tube formation assay. G Cell apoptosis was detected via flow cytometry. H, I WB was used to measure the protein expression of VEGFA and Bcl-2. *P < 0.05.