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Applied Biological Chemistry
Fig. 3 | Applied Biological Chemistry

Fig. 3

From: Piperine increases striatal levels of DA and TH and decreases α-syn and Aβ42 deposition in PDD mice by regulting autophagy: downexpression Beclin-1 and LC3B and upexpression p62

Fig. 3

Expression of TH positive neuron in the midbrain of PDD mice (× 200) (n = 3). Piperine could increase expression of TH positive neuron. Expression of TH positive neuron in all doses of piperine treated groups was more than that of the PDD model group (P < 0.05). Expression of TH positive neuron in all doses of piperine treated groups was less than that of the 3-methyladenine (3MA) group (P < 0.05). In addition, expression of TH positive neuron in all doses of piperine treated groups was decreased compared with that of madopar group (P < 0.05). The bar is 100 μm. The brown part is the cells with positive expression. *P < 0.05, **P < 0.01 vs model group; #P < 0.05, ##P < 0.01 vs 3MA group; $P < 0.05, $$P < 0.01 vs madopar group. A normal control group; B model group; C 10 mg/kg piperine group; D 20 mg/kg piperine group; E 40 mg/kg piperine group; F 3MA group; G rapamycin group; H madopar group

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