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Fig. 4 | Applied Biological Chemistry

Fig. 4

From: Piperine increases striatal levels of DA and TH and decreases α-syn and Aβ42 deposition in PDD mice by regulting autophagy: downexpression Beclin-1 and LC3B and upexpression p62

Fig. 4

Representative immunofluorescent assays of Beclin-1, LC3B and p62 levels (× 400) (n = 3). The Beclin-1 (I) and LC3B (II) expressions were decreased (P < 0.01), p62 (III) expression was increased (P < 0.05) in all doses of piperine treated groups compared with the model group.The Beclin-1 (I) and LC3B (II) expressions were increased (P < 0.05), p62(III) expression was declined (P < 0.01) in low and medium doses of piperine treated groups compared with 3-methyladenine (3MA) group.In addition, the Beclin-1 (I) and LC3B (II) expressions were reduced (P < 0.05), p62 (III) expression was augmented (P < 0.01) in high dose of piperine treated group compared with madoapr group. The Bar is 50 μm. The green part is the cells with positive expression. The blue part indicates the nucleus. *P < 0.05, **P < 0.01 vs model group; #P < 0.05, ##P < 0.01 vs 3MA group; $P < 0.05, $$P < 0.01 vs madopar group. A normal control group; B model group; C 10 mg/kg piperine group; D 20 mg/kg piperine group; E 40 mg/kg piperine group; F 3-MA group; G rapamycin group; H madopar group

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