Skip to main content
Applied Biological Chemistry
Fig. 5 | Applied Biological Chemistry

Fig. 5

From: Piperine increases striatal levels of DA and TH and decreases α-syn and Aβ42 deposition in PDD mice by regulting autophagy: downexpression Beclin-1 and LC3B and upexpression p62

Fig. 5

Results of midbrain histopathology (HE, × 200). Histopathology findings showed that the eosinophilic injured neurons showed nuclear pyknosis, irregular shape of cell body, eosin staining of cytoplasm and nucleus, and infiltration of inflammatory cells were observed in the model group compared to the normal control group. In addition, there was less eosinophilic neuron injury and less inflammatory cell infiltration in the 3-methyladenine (3MA), all doses of piperine and madopar treated groups. The blue part indicates the nucleus. The red part indicates the cytoplasm. A normal control group; B model group; C 10 mg/kg piperine group; D 20 mg/kg piperine group; E 40 mg/kg piperine group; F 3-MA group; G rapamycin group; H madopar group

Back to article page