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Applied Biological Chemistry
Fig. 7 | Applied Biological Chemistry

Fig. 7

From: Piperine increases striatal levels of DA and TH and decreases α-syn and Aβ42 deposition in PDD mice by regulting autophagy: downexpression Beclin-1 and LC3B and upexpression p62

Fig. 7

Representative western blot assays of α-syn, TH, HSP90, Beclin-1, LC3B and p62 expressions (× 400) (n = 3). The α-syn (I, II), HSP90 (I–IV), Beclin-1 (I–V), LC3B (I–VI) expressions were decreased (P < 0.01), TH (I–III) and p62 (I–VII) expressions were increased (P < 0.01) in high dose of piperine treated group compared with the model group. In addition, α-syn (I, II), HSP90 (I–IV), Beclin-1 (I–V) and LC3B (I–VI) expressions were lower (P < 0.01) in the medium dose of piperine group, TH (I–III) expression was higher (P < 0.01) than that of 3-methyladenine (3MA) group. Besides, the α-syn (I&II), HSP90 (I–IV), Beclin-1 (I–V), LC3B (I–VI), TH (I–III) and p62 (I–VII) expressions were reduced (P < 0.05). *P < 0.05, **P < 0.01 vs model group; #P < 0.05, ##P < 0.01 vs 3MA group; $P < 0.05, $$P < 0.01 vs madopar group. A normal control group; B model group; C 10 mg/kg piperine group; D 20 mg/kg piperine group; E 40 mg/kg piperine group; F 3MA group; G rapamycin group; H madopar group

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