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Applied Biological Chemistry
Fig. 2 | Applied Biological Chemistry

Fig. 2

From: Orlistat, a competitive lipase inhibitor used as an antiobesity remedy, enhances inflammatory reactions in the intestine

Fig. 2

A Effect of extracts from 100 mg of fecal matter from mice in HFDOrl group and its Dichloromethane (DCM) extract versus fecal extracts from ND and HFD-fed mouse groups and pure Orlistat (dissolved in DMSO) on ROS production in HCT-116-ARE cells challenged with and without t-BHP. Untreated, DMSO, and t-BHP-treated cells were used as controls. Intestinal epithelial mRNA expression of B SOD2, C Nrf2, and D caspase 3 analyzed by qRT-PCR for the three treatment groups; Normal Diet-fed (ND) as the control group, High fat diet-fed (HFD), and HFD-fed with Orlistat (HFDOrl) treatment groups. Data are presented as the mean concentration ± SEM. Different letters denote the significance of differences compared with the control (p < 0.05)

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