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Table 1 Mathematical kinetic equations used in this study

From: A novel 1,3,4-thiadiazole modified chitosan: synthesis, characterization, antimicrobial activity, and release study from film dressings

Kinetic model

Mathematical equation

Eq. no.

References

Zero-order model

\({A}_{t} = {A}_{o} +{K}_{o}t\)

(4)

[50]

First-order model

\(log {A}_{t} = log {A}_{o} - ({K}_{1} / 2.303)\)

(5)

[51]

Higuchi model

\({A}_{t} = {K}_{H} \times {t}^{0.5}\)

(6)

[52]

  1. Where At is the amount of drug released or dissolved at time t, Ao is the initial amount of drug in the solution, K0 is the zero-order release constant expressed in units of concentration/time. K1 is the first-order rate constant, and KH is the release rate constant for the Higuchi model