A novel 1,3,4-thiadiazole modified chitosan: synthesis, characterization, antimicrobial activity, and release study from film dressings

Applied Biological Chemistry

Table 7 Kinetics of the in-vitro release of Cs-E/B-ATT film dressing

Formula	Zero-order		First-order		Diffusion		t_1/2	Release Model
Formula	R²	K₀	R²	K₁	R²	k_H	t_1/2	Release Model
E1	0.996272	6.7855	− 0.9753	− 0.1783	0.988634	27.54107	7.368654	Zero
E2	0.997622	6.842167	− 0.9696	− 0.2616	0.994952	27.91073	7.307627	Zero
E3	0.999117	6.244167	− 0.9734	− 0.1927	0.991228	25.33804	8.007474	Zero
B1	0.986033	6.7665	− 0.9776	− 0.2172	0.976768	27.41608	7.389345	Zero
B2	0.99288	7.680833	− 0.9334	− 0.3578	0.978396	30.95761	6.50971	Zero
B3	0.990826	7.034167	− 0.9728	− 0.2679	0.982437	28.52732	7.108163	Zero

K₀ is the zero-order rate constant; K₁ is the first-order rate constant; K_H is the Higuchi constant