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Table 5 Effect of the synthesized chemical compound 3 and its coated form on the levels of α-Fetoprotein and α-L-Fucosidase in DEN-induced HCC in rat and therapeutic groups

From: Biochemical and histopathological studies of sulfonylurea derivative as a new chemotherapeutic agent against liver cancer in free- and nano-coated forms

Biomarkers/Groups

α-Fetoprotein ng/ml

α-L-Fucosidase (AFU)U/L

Control

0.60 ± 0.01a

2.22 ± 0.03a

Induced-HCC

% change

2.80 ± 0.03b

 + 366.66

12.90 ± 1.20b

 + 481.10

Treated-HCC (3)

% change

% improvement

1.45 ± 0.05c

 + 141.67

225.00

8.80 ± 0.70c

 + 296.39

184.69

Treated -HCC (Coated 3)

% change

% improvement

1.15 ± 0.03d

 + 91.67

275.00

7.00 ± 0.20d

 + 215.32

265.77

Treated-HCC (5-flurouracil)

% change

% improvement

1.30 ± 0.02e

 + 116.60

250.00

8.56 ± 1.00e

 + 285.59

195.50

  1. Data were expressed as means ± SD (n = 10).
  2. Groups with similar letters are not significantly different; while, those with different Letters are significantly different at P ≤ 0.05