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Fig. 1 | Applied Biological Chemistry

Fig. 1

From: Diatom frustule silica extracted from Melosira nummuloides ameliorates acetaminophen-induced acute liver injury in mice

Fig. 1

Preventive effects of Diatom Frustule Silica (DFS) extracted from Melosira nummuloides on acetaminophen-induced acute liver injury (ALI) in mice. Mice were orally administered with 7.5 or 30 mg/kg DFS or 50 mg/kg silymarin once daily for seven consecutive days. Control and acetaminophen-treated groups were orally administered with saline. After oral administration of the last chemical and fasting for 12 h, mice were intraperitoneally injected with 300 mg/kg acetaminophen and sacrificed after 8 h. ALI was evaluated by measuring A serum alanine aminotransferase (ALT) and B aspartate aminotransferase (AST) activity levels, C hepatic malondialdehyde (MDA) content, and D glutathione (GSH) levels. E Representative liver tissues of each group for histopathological analysis were stained with hematoxylin and eosin at 100 ×magnification. The results are presented as the mean ± standard deviation (SD) (n = 6). ###Significantly different from the control group (p < 0.001). **Significantly different from the acetaminophen-treated group (p < 0.01). ***Significantly different from the acetaminophen-treated group (p < 0.001)

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