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Applied Biological Chemistry
Fig. 3 | Applied Biological Chemistry

Fig. 3

From: Gryllus bimaculatus extract protects against palmitate-induced β-cell death by inhibiting ceramide synthesis

Fig. 3

Ceramide synthesis plays an important role in PAL-induced β-cell death. MTT cell viability assay, total ceramide levels, and representative western blots of c-caspase-3 after 0.5 mM PAL treatment in A CerS1-overexpressed, B CerS4-overexpressed, and C CerS6-overexpressed or D FB1-treated MIN6 cells (n = 3). Values are expressed as mean ± SEM compared to control group; *P < 0.05, **P < 0.01, ***P < 0.001 and compared to PAL-treated group; #P < 0.05, ##P < 0.01, ###P < 0.001. All experiments were performed in triplicate. PAL palmitate, c-caspase-3 cleaved caspase-3, CerS ceramide synthase, FB1 fumonisin B1, GB Gryllus bimaculatus, Con control (untreated)

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