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Applied Biological Chemistry
Fig. 7 | Applied Biological Chemistry

Fig. 7

From: Circular RNA pyridoxal kinase (circPDXK) involves in the progression of ovarian cancer and glycolysis via regulating miR-654-3p and hexokinase II

Fig. 7

In vivo role of circPDXK dysregulation in OVCA. A–F A2780 cells stably transfected with sh-NC and sh-circPDXK were harvested for nude mice xenograft tumor model experiment (n = 5 mice/group). A Most representative image of xenograft tumors in each group was shown. B, C Tumor volume and weight were shown. D QPCR detected relative RNA expression of circPDXK, miR-654-3p, and HK2, and E western blotting measured relative protein expression of HK2, ki67, Bax, and E-cadherin in tissue extract of xenograft tumors in each group. F IHC showed the in situ expression of HK2 and ki67 in one randomly selected xenograft tumor in each group. *, P < 0.05; **, P < 0.01; ***, P < 0.001

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