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Fig. 2 | Applied Biological Chemistry

Fig. 2

From: Anti-inflammatory effect of taxifolin in TNF-α/IL-17A/IFN-γ induced HaCaT human keratinocytes

Fig. 2

Taxifolin regulates IκB and STAT3 protein activation in TNF-α signal pathway. A IκB phosphorylation in the presence of TNF-α was inhibited by taxifolin. Although similar expression levels of IκB protein were observed under various conditions, IκB phosphorylation was significantly inhibited by taxifolin, strongly suggesting an anti-inflammatory activity of taxifolin through regulation of IκB phosphorylation. B p-IκB/IκB level was quantified with ImageJ program. C Taxifolin inhibited STAT3 phosphorylation as a concentration-dependent manner. GAPDH was used as a loading control. D Quantification of p-STAT3/STAT3 level with ImageJ program. ##, p < 0.01 versus untreated control; *, p < 0.05 and **, p < 0.01 versus TNF-α treated group

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