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Fig. 4 | Applied Biological Chemistry

Fig. 4

From: Anti-inflammatory effect of taxifolin in TNF-α/IL-17A/IFN-γ induced HaCaT human keratinocytes

Fig. 4

Taxifolin down-regulates phosphorylation of IκB/STAT3 in TNF-α + IL-17A + IFN-γ treated HaCaT cells. A IκB and phospholated IκB protein levels were determined by western blot analysis. GAPDH was used as a loading control. B Quantification of p-IκB/IκB levels using ImageJ program. C STAT3/pSTAT3 protein level validated by western blot analysis. D Quantification of p-STAT3/STAT3 levels using Image J program. E Taxifolin suppress inflammatory cytokine and chemokine expression by inhibiting IκB/STAT3 protein phosphorylation in a human keratinocyte psoriasis-like model. ##p < 0.05 and ###p < 0.001 versus untreated control, **p < 0.01 and ***p < 0.001 versus the group treated with TNF-α + IL-17A + IFN-γ

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