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Applied Biological Chemistry
Fig. 3 | Applied Biological Chemistry

Fig. 3

From: Knockdown of circ_0006872 alleviates CSE-induced human bronchial epithelial cells injury in chronic obstructive pulmonary disease

Fig. 3

Circ_0006872 acts as a sponge for miR-485-3p. A The binding site of miR-485-3p on circ_0006872 predicted by circinteractome database was listed. B The transfection efficiency detection. C, D The interaction between miR-485-3p and circ_0006872 was confirmed using dual-luciferase reporter assay and RNA pull-down assay. E The expression level of miR-485-3p was detected using qRT-PCR in non-smokers (n = 35), smokers (n = 35), and smokers with COPD (n = 35). F The correlation between miR-485-3p and circ_0006872 expression level in smokers with COPD (n = 35) was analyzed by Pearson’s correlation coefficient assay (r=-0.8966, P < 0.001). G Levels of miR-485-3p in16HBECs exposed to different concentrations of CSE. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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