Some novel peptides containing a modified pyrazolopyrimidine moiety: design, synthesis, and in vitro antibacterial screening

Applied Biological Chemistry

Table 2 MIC (μg/mL) of the newly synthetized compounds against different bacterial species

Compound	MIC (µg/mL)^a
	Gram-positive bacteria		Gram-negative bacteria
	Staphylococcus aureus ATCC 29213	Enterococcus faecalis ATCC 29212	Escherichia coli ATCC 25922	Pseudomonas aeruginosa ATCC 27853
Ciprofloxacin	0.2	0.4	0.02	3
4	0.3	0.6	0.6	4
5	0.25	0.6	0.8	3.5
10	0.08	0.2	0.16	2
11	0.05	0.31	0.25	2
13	0.02	0.01	0.13	2
14	0.03	0.01	0.13	2.5
15	0.02	0.1	0.1	1
17	0.01	0.08	0.11	0.9