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Applied Biological Chemistry
Fig. 1 | Applied Biological Chemistry

Fig. 1

From: Filbertone, (2E)-5-methyl-2-hepten-4-one, regulates thermogenesis and lipid metabolism in skeletal muscle of a high-fat diet fed mice

Fig. 1

Delineation of filbertone regulated genes and pathways in skeletal muscle. A Volcano plot of differentially expressed genes (DEGs) between high-fat diet (HFD) and HFD supplemented with Filbertone (HFD + Fil). DEGs involved the thermogenesis pathway were labeled. Genes having significant differences (p < 0.05 and |log2 (Fold Change)| >0.3) were indicated by colored plots. Red plots represented genes that were up-regulated by HFD + Fil compared to HDF whereas blue plots represented genes that were down-regulated. B Bar plot depicting the most enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for DEGs. The x-axis depicts the number of genes enriched in a specific pathway, with the color indicating the change in p-value. C Heatmap of certain enriched pathways. Following KEGG pathway analysis of upregulated genes by filbertone, the gene sets involved in thermogenesis, oxidative phosphorylation and branched chain amino acids (BCAAs) degradation pathways were visualized (n = 4 per group)

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