Table 2 Top 10 Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways with up and down regulated genes by filbertone treatment
A. KEGG pathways with up-regulated genes | |||
|---|---|---|---|
Ranking | Term | Gene count | P-value |
1 | Metabolic pathways | 87 | 4.10E-14 |
2 | Thermogenesis | 28 | 7.80E-12 |
3 | Fatty acid degradation | 13 | 2.60E-09 |
4 | Oxidative phosphorylation | 19 | 3.50E-09 |
5 | Valine, leucine and isoleucine degradation | 12 | 9.00E-08 |
6 | Diabetic cardiomyopathy | 21 | 1.70E-07 |
7 | Non-alcoholic fatty liver disease | 17 | 1.10E-06 |
8 | PPAR signaling pathway | 13 | 1.40E-06 |
9 | Chemical carcinogenesis—reactive oxygen species | 20 | 1.60E-06 |
10 | Fatty acid metabolism | 11 | 2.00E-06 |
B. KEGG pathways with down-regulated genes | |||
|---|---|---|---|
Ranking | Term | Gene count | P-value |
1 | Pathways in cancer | 35 | 3.50E-07 |
2 | Platelet activation | 14 | 1.10E-05 |
3 | Breast cancer | 14 | 6.20E-05 |
4 | Focal adhesion | 16 | 1.20E-04 |
5 | Prostate cancer | 11 | 1.50E-04 |
6 | Human papillomavirus infection | 22 | 2.10E-04 |
7 | Small cell lung cancer | 10 | 4.40E-04 |
8 | Endocrine resistance | 10 | 4.40E-04 |
9 | EGFR tyrosine kinase inhibitor resistance | 9 | 6.70E-04 |
10 | MicroRNAs in cancer | 18 | 1.20E-03 |