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Antitumor components isolated from the heartwood extract of Dalbergia odorifera

Journal of the Korean Society for Applied Biological Chemistry volume 52, pages 375–379 (2009)Cite this article

Abstract

Ongoing search for promising antitumor components from plant resources, we found that the methanol extract from the heartwood of Dalbergia odorifera (Leguminosae) demonstrated a significant inhibition on the proliferation of human tumor cell lines including multidrug resistant cells in vitro. Intensive bioassay-guided purification of the extract finally led to the isolation of seven flavonoids and two phenolic components as active constituents for antitumor property, in vitro, i.e., medicarpin (1), 2-hydroxy-3,4-dimethoxybenzaldehyde (2), formononetin (3), tectorigenin (4), mucronulatol (5), (3R)-5′-methoxyvestitol (6), hydroxyobtustyrene (7), liquiritigenin (8), and (3R)-calussequinone (9), respectively.

Abbreviations

MDR:

multi drug resistant

NMR:

nuclear magnetic resonance spectrometry

RT-PCR:

reverse transcriptasepolymerase chain reaction

TLC:

thin layer chromatography

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Authors and Affiliations

  1. Biomaterials Research Center, Korea Research Institute of Chemical Technology, 305-606, Daejeon, Republic of Korea

    Chun Whan Choi, Yeon Hee Choi, Mi-Ran Cha, Young Sup Kim, Gyu hwan Yon, Sang Un Choi & Shi Yong Ryu

  2. College of Pharmacy, Chungnam National University, 305-764, Daejeon, Republic of Korea

    Chun Whan Choi, Mi-Ran Cha & Young Ho Kim

  3. College of Forest Science, Kookmin University, 136-702, Seoul, Republic of Korea

    Young-Kyoon Kim

Authors
  1. Chun Whan Choi
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  2. Yeon Hee Choi
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  3. Mi-Ran Cha
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  4. Young Sup Kim
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  5. Gyu hwan Yon
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  6. Young-Kyoon Kim
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  7. Sang Un Choi
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  8. Young Ho Kim
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  9. Shi Yong Ryu
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Choi, C.W., Choi, Y.H., Cha, MR. et al. Antitumor components isolated from the heartwood extract of Dalbergia odorifera . J. Korean Soc. Appl. Biol. Chem. 52, 375–379 (2009). https://doi.org/10.3839/jksabc.2009.067

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  • DOI: https://doi.org/10.3839/jksabc.2009.067

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