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Inhibitory effect of populoside from the bark of Populus nigra on aldose reductase

Journal of the Korean Society for Applied Biological Chemistry volume 53, pages 729–733 (2010)Cite this article

Abstract

Bark extract of Populus nigra was examined as a possible inhibitor of aldose reductase, a key enzyme involved in diabetic complications. The aqueous acetone extract of P. nigra was subjected to gel filtration chromatography to produce an active compound, populoside, which inhibited aldose reductase with 50% inhibitory value of 18.55 μM in a non-competitive manner. Populoside also inhibited sorbitol accumulation by 48.84% at 50 μM. These results suggested that the P. nigra-derived component populoside has the potential to be used in the treatment of diabetic complications.

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Authors and Affiliations

  1. Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, 200-702, Chuncheon, Republic of Korea

    Yeon Sil Lee & Soon Sung Lim

  2. Department of Agriculture, Yanbian University, 133000, Yan Ji, Jilin Prov, China

    Cheng-Bi Cui

  3. Institute of Natural Medicine, Hallym University, 200-702, Chuncheon, Republic of Korea

    Jin Kyu Kim, Jae-Yong Lee & Soon Sung Lim

  4. Departement of Forest Biomaterials Engineering, Kangwon National University, 200-701, Chuncheon, Republic of Korea

    Young Soo Bae

  5. Depratment of Biochemistry, Hallym University, 200-702, Chunchenon, Republic of Korea

    Jae-Yong Lee

  6. Department of Food Science and Nutrition, Hallym University, 200-702, Chunchenon, Republic of Korea

    Il-Jun Kang & Soon Sung Lim

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  1. Yeon Sil Lee
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  2. Cheng-Bi Cui
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  3. Jin Kyu Kim
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  4. Young Soo Bae
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  5. Jae-Yong Lee
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  7. Soon Sung Lim
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Correspondence to Soon Sung Lim.

Additional information

YSL and C-BC contributed equally.

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Lee, Y.S., Cui, CB., Kim, J.K. et al. Inhibitory effect of populoside from the bark of Populus nigra on aldose reductase. J. Korean Soc. Appl. Biol. Chem. 53, 729–733 (2010). https://doi.org/10.3839/jksabc.2010.110

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  • DOI: https://doi.org/10.3839/jksabc.2010.110

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