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Constituents of the stem of Angelica gigas with rat lens aldose reductase inhibitory activity

Journal of the Korean Society for Applied Biological Chemistry volume 54, pages 194–199 (2011)Cite this article

Abstract

Eleven compounds were isolated from the stem of Angelica gigas. On the basis of spectral data, these compounds were identified as isoimperatorin (1), 7-methoxy-5-prenyloxycoumarin (2), imperatorin (3), decursin (4), bergapten (5), psoralen (6), xanthotoxin (7), p-hydroxyphenethyl trans-ferulate (8), visamminol (9), scopoletin (10), and 3′-hydroxyxanthyletin (11). All isolates were evaluated in vitro for their inhibitory activities on the rat lens aldose reducatase. Tested compounds (1-11) exhibited inhibitory activities against rat lens aldose reductase with IC50 values ranging from 2.59 to 191.91 μM.

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Authors and Affiliations

  1. College of Pharmacy, Kangwon National University, 200-701, Chuncheon, Republic of Korea

    Hyun Young Park & Yong Soo Kwon

  2. Speciality Crops Experimental Stations, GARES, 200-150, Chunchon, Republic of Korea

    Soon Bae Kwon & Nam Kee Heo

  3. College of Medicine, Kangwon National University, 200-701, Chuncheon, Republic of Korea

    Wan Joo Chun

  4. Oriental Bio-Herb Research Institute, Kangwon National University, 200-701, Chuncheon, Republic of Korea

    Myong Jo Kim

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  1. Hyun Young Park
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Correspondence to Yong Soo Kwon.

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Park, H.Y., Kwon, S.B., Heo, N.K. et al. Constituents of the stem of Angelica gigas with rat lens aldose reductase inhibitory activity. J. Korean Soc. Appl. Biol. Chem. 54, 194–199 (2011). https://doi.org/10.3839/jksabc.2011.032

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  • DOI: https://doi.org/10.3839/jksabc.2011.032

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