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Proteomic analysis of hepatotoxicity induced by titanium nanoparticles in mouse liver
Journal of the Korean Society for Applied Biological Chemistry volume 54, pages 852–859 (2011)
Abstract
Differentially expressed proteins in mouse liver caused by toxicity of titanium nanoparticles (TiO2 NPs) were screened. More than 1,400 protein spots in mouse liver were detected by twodimensional gel electrophoresis, and 15 proteins that showed greater than 2-fold expressional changes in response to TiO2 NPs were identified by liquid chromatography-tandem mass spectrometry. Of these, 12 proteins were down-regulated and 3 proteins were up-regulated upon treatment with TiO2 NPs. The 15 differentially expressed proteins could be used for detection of inflammation, apoptosis, and antioxidative reaction for treatment of acute hepatic damage by TiO2 NPs.
References
Allen EM, Anderson DG, Florang VR, Khanna M, Hurley TD, and Doorn JA (2010) Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: Implications for the mechanism of enzyme inhibition. Chem Res Toxicol 23, 1843–1850.
Andringa KK, King AL, Eccleston HB, Mantena SK, Landar A, Jhala NC, Dickinson DA, Squadrito GL, and Bailey SM (2010) Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: Novel molecular targets of disease and hepatoprotection. Am J Physiol Gastrointest Liver Physiol 298, G732–G745.
Bachhawat BK, Robinson WG, and Coon MJ (1956) Enzymatic carboxylation of beta-hydroxyisovaleryl coenzyme A. J Biol Chem 219, 539–550.
Campeau E, Dupuis L, León-Del-Rio A, and Gravel R (1999) Coding sequence mutations in the alpha subunit of propionyl-CoA carboxylase in patients with propionic acidemia. Mol Genet Metab 67, 11–22.
Chen J, Dong X, Zhao J, and Tang G (2009) In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection. J Appl Toxicol 29, 330–337.
Cheng MY, Hartl FU, and Horwich AL (1990) The mitochondrial chaperonin hsp60 is required for its own assembly. Nature 348, 455–458.
Chrzanowska A, Gajewska B, and Barañczyk-KuŸma A (2009) Arginase isoenzymes in human cirrhotic liver. Acta Biochim Pol 56, 465–469.
Cui Y, Gong X, Duan Y, Li N, Hu R, Liu H, Hong M, Zhou M, Wang L, Wang H, and Hong F (2010) Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles. J Hazard Mater 183, 874–880.
Cui Y, Liu H, Zhou M, Duan Y, Li N, Gong X, Hu R, Hong M, and Hong F (2011) Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 naoparticles. J Biomed Mater Res A 96, 221–229.
Deng X, Li W, Chen N, Sun Y, Wei H, Jiang Y, and He F (2009) Exploring the priming mechanism of liver regeneration: Proteins and protein complexes. Proteomics 9, 2202–2216.
Fu Q, Liu PC, Wang JX, Song QS, and Zhao XF (2009) Proteomic identification of differentially expressed and phosphorylated proteins in epidermis involved in larvalpupal metamorphosis of Helicoverpa armigera. BMC Genomics 10, 600.
Hsia YE, Scully KJ, and Rosenberg LE (1979) Human propionyl CoA carboxylase: some properties of the partially purified enzyme in fibroblasts from controls and patients with propionic acidemia. Pediatr Res 13, 746–751.
Hyka N, Dayer JM, Modoux C, Kohno T, Edwards CK 3rd, Roux-Lombard P, and Burger D (2001) Apolipoprotein A-I inhibits the production of interleukin-1beta and tumor necrosis factor-alpha by blocking contact-mediated activation of monocytes by T lymphocytes. Blood 97, 2381–2389.
Jeon YM, Park SK, Rhee SK, and Lee MY (2010) Proteomic profiling of the differentially expressed proteins by TiO2 nanoparticles in mouse kidney. Mol Cell Toxicol 6, 419–425.
Jeon YM, Son BS, and Lee MY (2011) Proteomic identification of the differentially expressed proteins in human lung epithelial cells by airborne particulate matter. J Appl Toxicol 31, 45–52.
Linnainmaa K, Kivipensas P, and Vainio H (1997) Toxicity and cytogenetic studies of ultrafine titanium dioxide in cultured rat liver epithelial cells. Toxicol In Vitro 11, 329–335.
Ma L, Zhao J, Wang J, Liu J, Duan Y, Liu H, Li N, Yan J, Ruan J, Wang H, and Hong F (2009) The acute liver injury in mice caused by nano-anatase TiO2. Nanoscale Res Lett 4, 1275–1285.
Marchitti SA, Brocker C, Orlicky DJ, and Vasiliou V (2010) Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress. Free Radic Biol Med 49, 1432–1443.
Merendino AM, Bucchieri F, Campanella C, Marcianò V, Ribbene A, David S, Zummo G, Burgio G, Corona DF, Conway de Macario E, Macario AJ, and Cappello F (2010) Hsp60 is actively secreted by human tumor cells. PLoS One 5, e9247.
Mohsen AW, Anderson BD, Volchenboum SL, Battaile KP, Tiffany K, Roberts D, Kim JJ, and Vockley J (1998) Characterization of molecular defects in isovaleryl-CoA dehydrogenase in patients with isovaleric acidemia. Biochemistry 37, 10325–10335.
Newton BW, Russell WK, Russell DH, Ramaiah SK, and Jayaraman A (2009) Liver proteome analysis in a rodent model of alcoholic steatosis. J Proteome Res 8, 1663–1671.
Park EJ, Yoon JH, Choi KH, Yi JH, and Park KS (2009) Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation. Toxicology 260, 37–46.
Park SK, Jeon YM, Son BS, Youn HS, and Lee MY (2011) Proteomic analysis of the differentially expressed proteins by airborne nanoparticles. J Appl Toxicol 31, 463–470.
Passadore I, Iadarola P, Di Poto C, Giuliano S, Montecucco C, Cavagna L, Bonino C, Meloni F, Fietta AM, Lisa A, Salvini R, and Bardoni AM (2009) 2-DE and LC-MS/MS for a comparative proteomic analysis of BALf from subjects with different subsets of inflammatory myopathies. J Proteome Res 8, 2331–2340.
Pecorari L, Marin O, Silvestri C, Candini O, Rossi E, Guerzoni C, Cattelani S, Mariani SA, Corradini F, Ferrari-Amorotti G, Cortesi L, Bussolari R, Raschellà G, Federico MR, and Calabretta B (2009) Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility. Mol Cancer 8, 58.
Sohaebuddin SK, Thevenot PT, Baker D, Eaton JW, and Tang L (2010) Nanomaterial cytotoxicity is composition, size, and cell type dependent. Part Fibre Toxicol 7, 22.
Sugimoto A, Ikeda H, Tsukamoto H, Kihira K, Takeda C, Hirose J, Hata T, Baba E, and Ono Y (2008) The mechanisms by which latanoprost free acid inhibits human carbonic anhydrase I and II. Biol Pharm Bull 31, 796–801.
Tan WH, Eichler FS, Hoda S, Lee MS, Baris H, Hanley CA, Grant PE, Krishnamoorthy KS, and Shih VE (2005) Isolated sulfite oxidase deficiency: A case report with a novel mutation and review of the literature. Pediatrics 116, 757–766.
Valério DA, Ferreira FI, Cunha TM, Alves-Filho JC, Lima FO, De Oliveira JR, Ferreira SH, Cunha FQ, Queiroz RH, and Verri WA Jr (2009) Fructose-1,6-bisphosphate reduces inflammatory pain-like behaviour in mice: Role of adenosine acting on A1 receptors. Br J Pharmacol 158, 558–568.
Valnot I, Kassis J, Chretien D, de Lonlay P, Parfait B, Munnich A, Kachaner J, Rustin P, and Rötig A (1999) A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency. Hum Genet 104, 460–466.
Van Summeren A, Renes J, Bouwman FG, Noben JP, van Delft JH, Kleinjans JC, and Mariman EC (2011) Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci 120, 109–122. Venkatraman A, Landar A, Davis AJ, Chamlee L, Sanderson T
Kim H, Page G, Pompilius M, Ballinger S, Darley-Usmar V, and Bailey SM (2004) Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicity. J Biol Chem 279, 22092–22101.
Vijayan V and Helen A (2007) Protective activity of Bacopa monniera Linn. on nicotine-induced toxicity in mice. Phytother Res 21, 378–381.
Vuilleumier N, Reber G, James R, Burger D, de Moerloose P, Dayer JM, and Roux-Lombard P (2004) Presence of autoantibodies to apolipoprotein A-1 in patients with acute coronary syndrome further links autoimmunity to cardiovascular disease. J Autoimmun 23, 353–360.
Wang J, Zhou G, Chen C, Yu H, Wang T, Ma Y, Jia G, Gao Y, Li B, Sun J, Li Y, Jiao F, Zhao Y, and Chai Z (2007) Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168, 176–185.
Wong LL, Fan ST, Man K, Sit WH, Jiang PP, Jor IW, Lee CY, Ling WL, Tam KT, and Wan JM (2011) Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity. Hum Exp Toxicol 30, 1369–1381.
Xiong D, Fang T, Yu L, Sima X, and Zhu W (2011) Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: acute toxicity, oxidative stress and oxidative damage. Sci Total Environ 409, 1444–1452.
Xu J, Futakuchi M, Iigo M, Fukamachi K, Alexander DB, Shimizu H, Sakai Y, Tamano S, Furukawa F, Uchino T, Tokunaga H, Nishimura T, Hirose A, Kanno J, and Tsuda H (2010) Involvement of macrophage inflammatory protein 1 alpha (MIP1alpha) in promotion of rat lung and mammary carcinogenic activity of nanoscale titanium dioxide particles administered by intra-pulmonary spraying. Carcinogenesis 31, 927–935.
Zhu G, Yan W, He HC, Bi XC, Han ZD, Dai QS, Ye YK, Liang YX, Wang J, and Zhong W (2009) Inhibition of proliferation, invasion, and migration of prostate cancer cells by downregulating elongation factor-1alpha expression. Mol Med 15, 363–370.
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Jeon, YM., Park, SK. & Lee, MY. Proteomic analysis of hepatotoxicity induced by titanium nanoparticles in mouse liver. J Korean Soc Appl Biol Chem 54, 852–859 (2011). https://doi.org/10.1007/BF03253172
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DOI: https://doi.org/10.1007/BF03253172