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Quinoline-2-carboxylic acid isolated from Ephedra pachyclada and its structural derivatives show inhibitory effects against α-glucosidase and α-amylase

Journal of the Korean Society for Applied Biological Chemistry volume 57, pages 441–444 (2014)Cite this article

Abstract

The aim of present study was to isolate a bioactive compound from the chloroform fraction of Ephedra pachyclada stems and to evaluate antidiabetic activities against α-glucosidase and α-amylase. According to various chromatographic and spectroscopic analyses, the bioactive compound of E. pachyclada was identified as quinoline-2-carboxylic acid. Based on the IC50 values of quinoline-2-carboxylic acid derivatives against α-glucosidase and α-amylase, quinoline-2-carboxylic acid (9.1 and 15.5 μg/mL) exhibited potent inhibitory activities, followed by quinoline-3-carboxylic acid (10.6 and 31.4 μg/mL), quinoline-4-carboxylic acid (60.2 and 152.4 μg/mL), and acarbose (66.5 and 180.6 μg/mL) against α-glucosidase and α-amylase, respectively. However, quinoline-2-carboxaldehyde, quinoline-3-carboxaldehyde, and quinoline-4-carboxaldehyde showed no inhibitory activities. Antidiabetic activity depended on the existence of a carboxyl group on quinoline for activities against α-glucosidase and α-amylase. Therefore, E. pachyclada and quinoline-2-carboxylic acid derivatives could be suitable as alternative synthetic antidiabetic agents.

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Authors and Affiliations

  1. Department of Bioenvironmental Chemistry and Institute of Agricultural Science & Technology, College of Agriculture & Life Science, Chonbuk National University, Jeonju, 561-756, Republic of Korea

    Hwa-Won Lee, Ji-Yeon Yang & Hoi-Seon Lee

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  1. Hwa-Won Lee
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  2. Ji-Yeon Yang
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  3. Hoi-Seon Lee
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Correspondence to Ji-Yeon Yang or Hoi-Seon Lee.

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Lee, HW., Yang, JY. & Lee, HS. Quinoline-2-carboxylic acid isolated from Ephedra pachyclada and its structural derivatives show inhibitory effects against α-glucosidase and α-amylase. J Korean Soc Appl Biol Chem 57, 441–444 (2014). https://doi.org/10.1007/s13765-014-4156-3

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