Skip to main content

Advertisement

Anti-diabetic effects of red rose flowers in streptozotocin-induced diabetic mice

Article metrics

  • 1489 Accesses

  • 1 Citations

Abstract

Diabetes mellitus is a common chronic metabolic disease that is of increasing concern, because it frequently leads to complications such as cardiovascular diseases and cancer. Plants have been studied as a potential source for anti-diabetics to supplement dietary modifications, insulin, and other medications. The components of green tea polyphenols can be changed by processes such as browning. This processing method was applied to the red rose flower to determine whether the processed or non-processed rose flower has an anti-diabetic effect on the streptozotocin-induced diabetic mouse. Aqueous extracts of processed and non-processed rose flowers were analyzed using liquid chromatography/mass spectrometry. The results show that the polyphenol content decreased with browning. The hemoglobin A1c level, an indicator of long-term diabetes, in diabetic mice after administration of extracts of browned rose flowers for 24 and 48 h were lower than those after administration of extracts of non-browned rose flowers. Moreover, the activity of aspartate transaminase, which is often high in diabetic patients, was low in all groups treated with rose flowers, whether they were non-browned or browned. Taken together, these results indicate that extracts from red rose flowers have long-term anti-diabetic effects, and that this effect is independent of the level of polyphenols in the extract.

References

  1. Al-Awadi FM and Gumaa KA (1987) Studies on the activity of individual plants of an antidiabetic plant mixture. Acta Diabetol 24, 37–41.

  2. Cooper R (2012) Green tea and theanine: health benefits. Int J Food Sci Nutr 63, 90–7.

  3. Goldberg IJ, Isaacs A, Sehayek E, Breslow JL, and Huang LS (2004) Effects of streptozotocin-induced diabetes in apolipoprotein AI deficient mice. Atherosclerosis 172, 47–53.

  4. Grover JK, Yadav S, and Vats V (2002) Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 81, 81–100.

  5. Hasani-Ranjbar S, Larijani B, and Abdollahi M (2009) A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. Inflamm Allergy Drug Targets 8, 2–10.

  6. Inzucchi S, Bergenstal R, Fonseca V, Gregg E, Mayer-Davis B, Spollett G et al. (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33, 62–9.

  7. Jaeger H, Janositz A, and Knorr D (2010) The Maillard reaction and its control during food processing. The potential of emerging technologies. Pathol Biol 58, 207–13.

  8. Koenig RJ, Peterson CM, Jones RL, Saudek C, Lehrman M, and Cerami A (1976) Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus. N Engl J Med 295, 417–20.

  9. Liu J, Xing J, and Fei Y (2008) Green tea (Camellia sinensis) and cancer prevention: a systematic review of randomized trials and epidemiological studies. Chin Med 3, 12.

  10. Maki KC, Reeves MS, Farmer M, Yasunaga K, Matsuo N, Katsuragi Y et al. (2009) Green tea catechin consumption enhances exercise-induced abdominal fat loss in overweight and obese adults. J Nutr 139, 264–70.

  11. Nannipieri M, Gonzales C, Baldi S, Posadas R, Williams K, Haffner SM et al. (2005) Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study. Diabetes Care 28, 1757–62.

  12. Shaw JE, Sicree RA, and Zimmet PZ (2010) Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pr 87, 4–14.

  13. Wang LF, Kim DM, and Lee CY (2000) Effects of heat processing and storage on flavanols and sensory qualities of green tea beverage. J Agr Food Chem 48, 4227–32.

Download references

Author information

Correspondence to Namhyun Chung or Yong Kwon Lee.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Keywords

  • anti-diabetic effect
  • hemoglobin A1c
  • plant browning
  • polyphenols
  • red rose flower