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Antibacterial and cytotoxic activities of Schiff base analogues of 4-aminoantipyrine

Journal of the Korean Society for Applied Biological Chemistry volume 57, pages 613–619 (2014)Cite this article

Abstract

Schiff base is the class of compounds showing wide range of biological activities having the azomethine (-N=CH-) active pharmacophore, which play major roles in their significant bio-activities. A series of Schiff base analogues of 4-aminoantipyrine analogues have been tested for bactericidal and cytotoxic activities against selected bacterial strains and brine shrimp (Artemia salina) nauplii, respectively. Of the compounds tested, two compounds showed a good inhibition of bacterial growth against E. coli and C. sakazakii, whereas three compounds demonstrated high cytotoxicity with LC50 values of 225, 480, and 581 ppm, in a short term bioassay using A. salina. Qualitative structure-cytotoxic activity relationships were studied using physicochemical parameters; a good correlation between clogP and cytotoxic activity was observed.

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Authors and Affiliations

  1. Division of Bioscience, Dongguk University, Gyeongju, 780-714, Republic of Korea

    Mohammad Sayed Alam & Dong-Ung Lee

  2. Food analysis and Research laboratory, Centre for Advance Research in Sciences, University of Dhaka, Dhaka, 1000, Bangladesh

    Md. Latiful Bari

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  1. Mohammad Sayed Alam
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  2. Dong-Ung Lee
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  3. Md. Latiful Bari
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Correspondence to Dong-Ung Lee.

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Alam, M.S., Lee, DU. & Bari, M.L. Antibacterial and cytotoxic activities of Schiff base analogues of 4-aminoantipyrine. J Korean Soc Appl Biol Chem 57, 613–619 (2014). https://doi.org/10.1007/s13765-014-4201-2

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