Table 2 IC50 values of compounds 1–9 on AR inhibition
From: Plant-derived molecules from Saussurea grandifolia as inhibitors of aldose reductase
Compound | Concentration (μg/mL) | Inhibitiona (%) | IC b50 (μM) |
|---|---|---|---|
1 | 10 | 96.0 | 1.45 |
5 | 80.8 | ||
0.1 | 21.1 | ||
2 | 10 | 74.8 | 8.34 |
5 | 51.2 | ||
1 | 23.5 | ||
3 | 10 | 60.1 | 14.66 |
5 | 34.3 | ||
1 | 8.1 | ||
4 | 10 | 21.6 | – |
5 | 10 | 50.5 | 22.83 |
5 | 31.2 | ||
1 | 15.7 | ||
6 | 10 | 97.7 | 0.34 |
1 | 69.5 | ||
0.1 | 45.7 | ||
7 | 10 | 87.2 | 0.32 |
1 | 65.9 | ||
0.1 | 46.9 | ||
8 | 10 | 95.4 | 0.08 |
0.1 | 64.6 | ||
0.05 | 45.7 | ||
9 | 10 | 24.9 | – |
TMGc | 5 | 78.5 | 5.16 |
1 | 59.0 | ||
0.5 | 32.2 |