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Table 2 IC50 values of compounds 19 on AR inhibition

From: Plant-derived molecules from Saussurea grandifolia as inhibitors of aldose reductase

Compound Concentration (μg/mL) Inhibitiona (%) IC b50 (μM)
1 10 96.0 1.45
5 80.8
0.1 21.1
2 10 74.8 8.34
5 51.2
1 23.5
3 10 60.1 14.66
5 34.3
1 8.1
4 10 21.6
5 10 50.5 22.83
5 31.2
1 15.7
6 10 97.7 0.34
1 69.5
0.1 45.7
7 10 87.2 0.32
1 65.9
0.1 46.9
8 10 95.4 0.08
0.1 64.6
0.05 45.7
9 10 24.9
TMGc 5 78.5 5.16
1 59.0
0.5 32.2
  1. aInhibition rate was calculated as a percentage with respect to the control value
  2. bIC50 value was calculated from least-squares regression analysis of the plot of the logarithm of three graded concentrations versus % inhibition
  3. cTMG was used as a positive control