Table 2 Inhibitory effects of compounds 1–8 on bacterial α-glucosidase
Compounds | α-glucosidase (S. cerevisae) | |
|---|---|---|
IC a50 (μM) | Kinetic mode (K i, μM)b | |
1 | 1.3 ± 0.1 | Noncompetitive (1.9 ± 0.4) |
2 | 14.1 ± 1.2 | Noncompetitive (2.3 ± 1.1) |
3 | 74.8 ± 2.3 | Noncompetitive (77.8 ± 1.8) |
4 | >100 | NTc |
5 | 17.8 ± 1.3 | Noncompetitive (26.8 ± 1.3) |
6 | >100 | NT |
7 | 21.6 ± 1.8 | Noncompetitive (18.2 ± 0.9) |
8 | >100 | NT |
Acarbose | 255.1 ± 15.6 | NT |
DNJ | 2.5 ± 0.1 | NT |