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Applied Biological Chemistry

Table 3 Pharmacokinetic parameters of myricetin (Dang et al. 2014)

From: Myricetin: biological activity related to human health

Parameters

Administration routes

p.o.

i.v.

Dose (mg/kg)

50

100

0.5

C max (ng/mL)a

1488.75 ± 200.78

2611.76 ± 1019.58

2232.16 ± 856.36

T max (h)b

6.4 ± 0.89

5.2 ± 3.03

0 (pre-dose)

t 1/2 (h)

2.78 ± 0.81

3.79 ± 0.75

6.99 ± 1.94

AUC0-∞ (ng·h/mL)c

13,731.13 ± 5,574.58

28,081.62 ± 10,982.45

1452.85 ± 170.30

CL (L/h/kg)d

–

–

0.35 ± 0.05

V d (L/kg)e

–

–

4.12 ± 1.52

Bioavailability (%)f

9.62

9.74

–

  1. aThe peak serum concentration of a drug after administration
  2. bThe amount of time for which a drug is present at maximum concentration in serum
  3. cThe total drug exposure over time
  4. dThe rate at which the drug is cleared from the blood
  5. eVolume of distribution, a proportionality constant between total amount of drug in the body and plasma concentrations
  6. fFraction of drug that reaches the blood stream when compared with the amount of the drug that is administered
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