Fig. 2From: Comparison and contrast of plant, yeast, and mammalian ER stress and UPRA schematic illustration of the unfolded protein response in mammals. IRE1 splices 26 nucleotides in XBP1 mRNA in the mammalian UPR. ATF6 is activated in the Golgi by S1P and S2P. The N-terminal domain of ATF6 is translocated to the nucleus for the induction of UPR gene expression. PERK activates UPR genes and functions in translational attenuationBack to article page