Quercetin and quercetin-3-β-d-glucoside improve cognitive and memory function in Alzheimer’s disease mouse

Applied Biological Chemistry

Table 1 Effects of Q and Q3G on spatial learning and memory impairment in Aβ_25–35-induced AD mice revealed by the Morris water maze test

Training day	Latency to reach hidden platform (second)
Training day	Normal	Control	Q	Q3G
1 day	56.22 ± 13.14	50.78 ± 16.66	57.78 ± 9.90	53.22 ± 15.89
2 day	54.72 ± 14.65	50.72 ± 15.50	37.44 ± 21.67	43.33 ± 19.05
3 day	30.89 ± 17.01	54.94 ± 9.42	26.44 ± 20.14	33.44 ± 20.35
Final test	22.33 ± 20.49^b	59.17 ± 2.04^a	17.83 ± 11.79^b	29.33 ± 8.33^b

Values are mean ± SD
Normal 0.9 % NaCl injection + oral administration of 0.5 % CMC; Control Aβ_25–35 injection + oral administration of 0.5 % CMC; Q Aβ_25-35 injection + oral administration of quercetin (30 mg/kg/day); Q3G Aβ_25–35 injection + oral administration of quercetin-3-β-D-glucoside (30 mg/kg/day)
^a,bMeans with different letters indicate significant differences (P < 0.05) by Duncan’s multiple range test