Table 2 Biological activities of thymosin beta 4

Migration: increased keratinocytes, corneal epithelial cells, stem cells, etc., decreased neutrophil migration

Gene expression: increased VEGF, angiopoietin, laminin-332, zyxin, etc., decreased  inflammatory mediators

Angiogenesis: increased endothelial precursor recruitment and migration, increased angiogenic factors

Cytoprotection: decreased oxidative stress, AGEs, ROS

Anti-apoptosis: many genes involved in apoptosis are regulated by thymosin beta 4

Anti-inflammation: decreased Nf-KappaB, inflammatory mediators, neutrophil infiltration, etc.

Anti-fibrotic: decreased myofibroblasts

Antimicrobial

Stem cell differentiation: tissue regeneration