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Applied Biological Chemistry
Fig. 5 | Applied Biological Chemistry

Fig. 5

From: Role of NADPH oxidase and its therapeutic intervention in TGF-β-mediated EMT progression: an in vitro analysis on HeLa cervical cancer cells

Fig. 5

The effect of candidate inhibitors targeting ROS-mediated redox signaling transduction kinases and EMT progression. Proteins extracted from HeLa cells treated with inhibitors targeting TGF-β signaling pathways, AKT, MEK/ERK, or MAPK proteins were analyzed using western blot for the expression of a NADPH oxidase (NOX4 and NOX2) and b EMT-associated transcription factors and mesenchymal markers. c Smad-7, an inhibitor of TGF-β signaling pathways, was overexpressed in HeLa cells and its effect on NADPH oxidases and EMT-associated transcription factors were analyzed

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