Table 3 Five signaling pathways related to allograft rejection were screened according to differentially expressed genes in PrxII+/+ (WT) and PrxII−/−
Pathway | Count | p-value | Down-regulated genes | Up-regulated genes |
|---|---|---|---|---|
Allograft rejection | 9 | 4.7387E−08 | Cd40/H2-T24/H2-Q7/H2-K1/H2-T23/H2-Q6/H2-D1/H2-T10/H2-Q1 | |
Antigen processing and presentation | 13 | 3.9502E−11 | Psme1/Tapbp/Tap2/Tap1/H2-T24 /H2-Q7/B2m/H2-K1/H2-T23/H2-Q6/H2-D1/H2-T10/H2-Q1 | |
Proteasome | 4 | 0.003105029 | Psme1/Psmb8/Psmb10/Psmb9 | |
Chemokine signaling pathway | 8 | 0.003985326 | Ccl8/Stat1/Cxcl9/Rasgrp2/Cxcl10/Ccl5/Stat2/Cxcl11 | Cx3cl1/Cxcr6 |
Complement and coagulation cascades | 7 | 6.9125E−05 | Serping1/C3/C2/C1s1/C1ra/C1s2/Cfb |