Preventive effect of Lactobacillus plantarum HFY09 on HCl/ethanol-induced gastric injury in mice

Applied Biological Chemistry

Table 5 The levels of ET-1, SP, SS and VIP in serum of mice (n = 10)

Group	ET-1 (ng/L)	SP (ng/L)	SS (ng/L)	VIP (ng/L)
Normal	70.91 ± 5.56^a	65.82 ± 4.14^a	211.97 ± 8.47^e	431.27 ± 28.55^e
Negative control	122.61 ± 12.51^d	152.51 ± 17.67^f	112.55 ± 2.59^a	212.92 ± 38.12^a
Ranitidine	85.23 ± 8.89^b	75.87 ± 6.04^b	189.61 ± 15.15^d	423.18 ± 20.43^e
LB	108.36 ± 14.93^c	129.35 ± 16.59^e	144.74 ± 13.55^c	312.87 ± 26.92^c
HFY09-H	92.80 ± 9.44^b	92.91 ± 5.87^c	152.51 ± 12.04^c	351.04 ± 34.56^d
HFY09-L	109.29 ± 12.51^c	103.29 ± 3.73^d	122.60 ± 4.93^b	268.59 ± 34.33^b

Values presented are the means ± SD. a–e In the same column, values with different letters are significantly different (P < 0.05) according to Duncan’s multiple-range test
Normal = normal mice; Negative control = mice treated with HCl/ethanol (10 mL/kg); Ranitidine = 50 mg/kg per day by gavage; HFY09 = mice treated with HCl/ethanol (15th day) and doses (L, H) of Lactobacillus plantarum HFY09 (10⁸, 10⁹ CFU/kg per day); LB = mice treated with HCl/ethanol (15th day) and Lactobacillus delbrueckii subsp. bulgaricus (10⁹ CFU/kg per day)