Preventive effect of Lactobacillus plantarum HFY09 on HCl/ethanol-induced gastric injury in mice

Applied Biological Chemistry

Table 6 The levels of IL-6, IL-12, TNF-α and IFN-γ in serum of mice (n = 10)

Group	IL-6 (ng/L)	IL-12 (ng/L)	TNF-α (ng/L)	IFN-γ (ng/L)
Normal	102.74 ± 10.01^a	6.89 ± 0.92^a	675.64 ± 63.24^a	487.99 ± 20.17^a
Negative control	183.82 ± 15.21^f	14.16 ± 1.22^e	1340.68 ± 163.49^e	821.75 ± 36.09^e
Ranitidine	113.49 ± 12.65^b	8.19 ± 0.85^b	881.84 ± 97.42^b	615.99 ± 79.51^b
LB	154.97 ± 14.62^e	12.51 ± 1.23^d	997.38 ± 73.06^c	764.75 ± 8.59^d
HFY09-H	127.51 ± 7.64^c	8.87 ± 1.24^b	938.40 ± 123.45^ab	683.67 ± 44.81^c
HFY09-L	134.19 ± 12.48^d	11.21 ± 0.96^c	1095.18 ± 84.21^d	853.74 ± 49.54^e

Values presented are the means ± SD. a–e In the same column, values with different letters are significantly different (P < 0.05) according to Duncan’s multiple-range test
Normal = normal mice; Negative control = mice treated with HCl/ethanol (10 mL/kg); Ranitidine = 50 mg/kg per day by gavage; HFY09 = mice treated with HCl/ethanol (15th day) and doses (L, H) of Lactobacillus plantarum HFY09 (10⁸, 10⁹ CFU/kg per day); LB = mice treated with HCl/ethanol (15th day) and Lactobacillus delbrueckii subsp. bulgaricus (10⁹ CFU/kg per day)