Table 1 Chemical identity and the source of marine seaweed compounds showing promising results against 3CLpro of SARS-CoV-2

1

BZ004

Zonariu toumefortii

5-[(1S,3Z)-1-hydroxyhex-3-en-1-yl]-8-[(2Z, 5Z)-10-oxo-10-(2,4,6-trihydroxyphenyl)deca-2,5-dien-1-yl]-2-phenyl-1H, 2H,3H,5H,8H-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione

2

GA004

(Nigricanoside A)

Avrainvillea nigricans

2,3-Dihydroxypropyl (5ξ)-6-O-[(4Z,8E, 13Z)-1-carboxy-10-{[(4Z, 9E)-15-carboxy-8,11-dihydroxy-4,9-pentadeca dien-7-yl]oxy}-11-hydroxy-4,8,13-nonadecatrien-7-yl]-α-L-arabino -hexopyranoside

3

GA005

(Nigricanoside B)

Avrainvillea nigricans

2,3-Dihydroxypropyl (5ξ)-6-O-[(4Z,8E,13Z, 16Z)-1-carboxy -10-{[(4Z,9E)-15-carboxy-8,11-dihydroxy-4,9-penta decadien-7-yl] oxy}-11-hydroxy-4,8,13,16-nonadecatetraen-7-yl]-α-L-arabino-hexopyranoside

4

GA006

(Nigricanoside A dimethyl ester)

Avrainvillea nigricans

2,3-Dihydroxypropyl 6-O-[(5Z,9E,14Z)-11-{[(4Z,9E)-8,11-di hydroxy-16-methoxy-16-oxo-4,9-hexadecadien-7-yl]oxy}-12-hydroxy-1-methoxy-1-oxo-5,9,14-icosatrien-8-yl]-β-D-galacto pyranoside

5

GA007

(Nigricanoside B dimethyl ester)

Avrainvillea nigricans

methyl (5Z,9E,14Z,17Z)-11-{[(4Z,9E)-8,11-dihydroxy-16-methoxy -16-oxohexadeca-4,9-dien-7-yl]oxy}-8-{[6-(2,3-dihydroxypropoxy)-3,4,5-trihydroxyoxan-2-yl]methoxy}-12-hydroxyicosa-5,9,14,17-tetraenoate

6

RC002

(Callophysin A)

Callophycus oppositifolius

2-[(4-hydroxyphenyl)methyl]-1H,2H, 3H,4H,9H-pyrido[3,4-b] indole-3-carboxylic acid

7

RL497

Laurencia brongniartii

4,6-dibromo-2,3-dimethanesulfinyl-1H-indole

8

RP011

Polysiphonia lanosa

3-bromo-5-(hydroxymethyl)benzene-1,2-diol

9

RR019

Rhodomela confervoides

methyl 4-{[({3-bromo-2-[(2,3-dibromo-4,5-dihydroxy phenyl) methyl]-4,5-dihydroxy phenyl}methyl)[(2,3-dibromo-4,5-dihydroxy phenyl)methyl]carbamoyl] amino}butanoate